MAPT and synucleinopathy: Similar to the distribution of PFF-induced synucleinopathy and tau deposition, inclusions of aSyn and TDP-43 were only partly colocalized in cells exposed to aSyn PFFs and rarely colocalized in mice exposed to aSyn PFFs calling into question the significance of any synergistic effect of aSyn on TDP-43 aggregation in disease [62, 68].