This year, using state-of-the-art tissue procedures, Llorens-Martín and colleagues from Spain have identified thousands of doublecortin-positive (DCX+) immature neurons in the dentate gyrus of healthy adults between the ages of 43 to 87 and compared them to the significantly fewer DCX+ found in Alzheimer’s disease patients [2]. The gene discussed is DCX; the disease is early-onset autosomal dominant Alzheimer disease.