Decreasing insulin resistance through insulin-sensitizing drugs (e.g., metformin, rosiglitazone, pioglitazone, and d-chiro-inositol) and/or lifestyle treatments could improve the reproductive and metabolic outcomes for patients with PCOS (Morley et al., 2017; Anithasri et al., 2019). Here, INS is linked to polycystic ovary syndrome.