In fact, overexpression of DNMT3b was shown to result in aberrant DNA methylation in T-cell acute lymphoblastic leukemia (Poole et al., 2017) and to be significantly correlated with unfavorable prognosis in various human malignancies (Kim et al., 2006; Park et al., 2006; Vallböhmer et al., 2006; Wang et al., 2006; Lin et al., 2007; Xing et al., 2008). The gene discussed is DNMT3B; the disease is T-cell acute lymphoblastic leukemia.