Second, the CTSW promoter region is not accessible in normal mammary cells or breast cancer cells (HMEC, MCF-7, T-47D) but is open in CD8+ T cells, CD56+ NK cells, CD34+ common myeloid progenitor cells, and the acute T cell leukemia cell line Jurkat (Figure 2C), according to the DNase I hypersensitive sites sequencing (DNase-seq) data from ENCODE and the Roadmap Epigenomics Project. This evidence concerns the gene CD8A and breast carcinoma.