In vitro, the HCC cell lines expressing IL-37 attract NK CD57(+) cells which, in turn, are cytotoxic with regard to the HCC lines (143); (ii) the profusion of NK CD57(+) cells and the elevated level of hepatic expression of IL-37 are associated with improved overall survival (143); (iii) IL-37 has an anti-tumoral effect during HCC. The gene discussed is IL37; the disease is hepatocellular carcinoma.