IL1A and liver disorder: It is the demonstration that this phenomenon leads to the constitution of an innate memory of cells of myeloid origin that led to the proposal of the new concept of “trained immunity.” We have attempted here to apply the concept of trained immunity to liver diseases, based on the role of the IL-1 superfamily, first of all IL-1β but also IL-18 and IL-33, in modulating innate lymphoid immunity carried by NK cells, ILC or innate T-αβ lymphocytes.