In a murine model, a high fat diet (HFD)-induced steatohepatitis was associated with upregulation of IL-33 but IL-33 deficiency did not affect severity of liver inflammation or liver fibrosis, suggesting that endogenous IL-33 has no effect on the progression of fibrosis during experimental steatohepatitis (109). This evidence concerns the gene IL33 and Hepatic fibrosis.