IL1B and Hepatic fibrosis: Accordingly, IL-1β and/or IL-1α-deficient mice have demonstrated less diet-induced inflammation and liver fibrosis, as attested by lower serum transaminases and serum amyloid alpha concentrations, as well as decreased expression of inflammatory and fibrosis transcripts such as IL-6, TNFα, P-Selectin, Cxcl1, and TGFβ, as compared to WT controls (102).