IL4 and food allergy: · Maternal allergen sensitization through skin prevented food anaphylaxis, allergen-specific IgE production, serum IL-4, serum mMCP1, and intestinal mast cell expansion in BALB/c offspring. · The protective effects of food allergy by OVA-sensitized dam were abolished in Fcgrt−/−. · Offspring of naïve dams supplemented with OVA-IgG1-IC showed increase of serum OVA-IgG1-IC levels, OVA-specific Treg in mesenteric lymph node at weaning, and protection against food allergy.