· IFN-γ-dependent prevention of experimental asthma in BALB/c offspring · A significant reduction in acetylation levels of histone 4 of the Il4 promoter after OVA challenge · The preventive effect was completely abolished in heterozygous offspring of A. lwoffii F78-treated Tlr2/3/4/7/9−/− dam. This evidence concerns the gene IFNG and asthma.