However, the suppression of prevalence of food allergy and milk sensitization was significant only before 2 years of age and none of the prevalence in food allergy, atopic dermatitis, allergic rhinitis, asthma, any atopic disease, and serum IgE levels were differed at 7 years of age (29), indicating that maternal and offspring avoidance of allergenic foods is not effective in prevention of allergic diseases in offspring. Here, IGHE is linked to allergic disease.