BCR and hepatitis C virus infection: Accordingly, levels of hyperactivated, exhausted CD19+CD21lowCD27− tissue-like memory B-cells and reduced B-cell receptor (BCR)–induced immunoglobulin-secreting capacity, as observed frequently in individuals with hepatitis C infection (20), Sjogren's syndrome (21, 22), and HIV (23, 24), might become apparent also in pediatric patients suffering from cGVHD.