Here, we review the involvement of the CXCL12/CXCR4/ACKR3 axis in some of the most prevalent autoimmune diseases: psoriasis (146), multiple sclerosis (161), rheumatoid arthritis (162), lupus (155), type I diabetes (T1D) (163), and inflammatory bowel disease (164, 165). This evidence concerns the gene CXCR4 and autoimmune disease.