In this particular context of unhealthy aging, characterized by vascular damage, endothelial cell-MR activation can amplify cardiovascular adverse outcomes, exacerbating vascular stiffness through the induction of augmented reactive oxygen species production, collagen deposition, and vascular inflammation (9, 94, 95), resulting in altered vasodilation, endothelial dysfunction, and atherosclerosis (Figure 2). The gene discussed is NR3C2; the disease is atherosclerosis.