However, studies have demonstrated that endothelial cell-specific MR deficiency or MR antagonists treatment in mice prevents hormone- or diet-induced increases in endothelial cell stiffness, oxidative stress, leukocyte adhesion and the associated decrease in nitric oxide (NO) production (59, 60), which are prominent features of age-related vascular dysfunction (48). Here, NR3C2 is linked to hyperinsulinemic hypoglycemia, familial, 4.