Importantly, recommended treatment of resistant hypertension considers the addition of low-dose spironolactone (up to 50 mg/day) to existing therapy also in the elderly population, where loop diuretics and alpha-blockers should be avoided due to their association with falls (128), extending the possibility of pharmacological MR antagonism in the aging hypertensive population. The gene discussed is NR3C2; the disease is Hypertension resistant to conventional therapy.