TLR2 and hyperlipidemia: Considering that VLDLR is important in postprandial chylomicron and VLDL clearance (Goudriaan et al., 2004), the upregulation of VLDLR is thought to lower serum lipids, which is opposite of the hyperlipidemia phenotype seen in both offspring-pLPS and TLR2-deficient offspring-pLPS.