The association between DHA supplementation, increased concentrations of the precursor of resolvins/protectins, and lower concentrations of pro-inflammatory LMs, such as LTB4, together with a tendency to a decrease in neutrophil infiltration also observed upon supplementation, provides evidence in support of a potential anti-inflammatory activity of n-3 PUFA supplementation in CF subjects. The gene discussed is CD59; the disease is cystic fibrosis.