Although there are significant limitation associated with the comparison with COPD subjects (i.e., there is no possibility to match age between the two groups), the results obtained in CF subjects when compared with COPD patients showed a marked unbalance between pro-inflammatory mediators derived from AA and 17OH-DHA, that represents the precursor of protectins and resolvins, with both higher concentrations of pro-inflammatory LTB4 and PGE2, and lower concentrations of 17OH-DHA in CF subjects. This evidence concerns the gene CD59 and chronic obstructive pulmonary disease.