LC/MS/MS analysis of sputum samples detected significant amounts of several LMs, such as LTB4, PGE2, and 15-HETE, as well as 17OH-DHA, which represents the precursor of protectin and resolvins; RvD2 could be detected at a s/n ratio above 10 only in a sample from the COPD basal group (1.7 ng/ml), but in none of the CF samples obtained before supplementation with DHA. This evidence concerns the gene CD59 and cystic fibrosis.