Studies show that inhibition of the PI3K/AKT pathway limits the glycolytic process and deprives tumor cells of energy supply (Chen et al., 2016; Cretella et al., 2018), which could explain the reduction of ROS content (Robey and Hay, 2009; Zhao et al., 2017) and the elevation of cell autophagy level (Jin and White, 2007; Cheong, 2015; Liu et al., 2017). This evidence concerns the gene AKT1 and neoplasm.