APP and Alzheimer disease: For example, induced expression of HSPA1 in APP/PSEN1 mice decreased the level of inflammatory cytokines (Sun et al., 2017), whereas transgenic overexpression of HSPA1 or HSPB1 in mouse models of AD was able to reduce Aβ plaque formation and cognitive dysfunctions (Hoshino et al., 2011; Tóth et al., 2013) In addition, HSPB8 can promote motor neuron survival by diminishing the toxic effects of dipeptide repeat proteins (Cristofani et al., 2018; Zhu and Reiser, 2018).