Particularly, since IL-1 was considered the master mediator of inflammatory pathway in both sJIA and AOSD (Pascual et al., 2005; Church et al., 2008; Mellins et al., 2011; Gerfaud-Valentin et al., 2014), an increasing experience of IL-1 blockade has matured over time (Lequerré et al., 2008; Nigrovic et al., 2011; Quartier et al., 2011; Nordström et al., 2012; Ortiz-Sanjuán et al., 2015; Pardeo et al., 2015; Sfriso et al., 2016; Colafrancesco et al., 2017). This evidence concerns the gene IL1B and adult-onset Still disease.