APP and Alzheimer disease: Several experimental AD models linked to APP overexpression or Aβ peptides treatments are characterized as well by mitochondrial fragmentation and abnormal mitochondrial distribution along the neurons due to an alteration of mitochondrial fusion and fission proteins levels (Wang et al., 2008b; Du et al., 2010; Zhao et al., 2010; Calkins and Reddy, 2011; Wang et al., 2017).