In vitro APP/PSEN1-overexpressed hippocampal neuroblastoma In vitro NMN-treated organotypic hippocampal slice cultures (OHCs)In vivo APP/PSEN1 mice In vivo Aβ oligomer-infused ratsIn vivo Tg2576 miceIn vivo Aβ and tau Caenorhabditis elegans models. The gene discussed is MAPT; the disease is neuroblastoma.