Importantly, the increase in IDO expression was found in microglia, astrocytes, and neurons, with the primary product found in proximity to senile plaques and neurofibrillary tangles in post-mortem AD brain being Quin, the microglial product (Guillemin et al., 2005; Bonda et al., 2010). The gene discussed is IDO1; the disease is Alzheimer disease.