The P2X7–NLRP3 pathway is a case in point where microglia-driven neuroinflammation may play a role in AD causality (Heneka et al., 2013), and there has been growing interest in probing the role of pathogenic Aβ in neuroinflammation, although the exact mechanism of its involvement is still unknown (Illes et al., 2019; Martin et al., 2019; Thawkar and Kaur, 2019). This evidence concerns the gene P2RX7 and Alzheimer disease.