This could be especially problematic in neurodegenerative disorders such as AD where neuroinflammation associated with plaques and tangles is predicted to increase KMO expression, thus more readily converting KYN to 3-HK and Quin (Guillemin et al., 2003a; Guillemin et al., 2005; Bonda et al., 2010). Here, KMO is linked to Alzheimer disease.