GFAP and Alzheimer disease: Figures 6A–C are the pathological results of the corresponding region of sham operated controls. The total number of GFAP-positive astrocytes was expressed as the mean number per field of view. A significant increase in the number of GFAP-positive astrocytes was observed in the hippocampus CA1 region of the AD model, as compared to sham rats (Figure 7B).