The IL-1 family of ligands and receptors are associated with both acute and chronic inflammation (Gabay et al., 2010; Dinarello, 2011), and IL-1α is an intracellular cytokine involved in various immune responses and inflammatory processes (Schett et al., 2016), that is known to be upregulated in cardiovascular diseases (Pfeiler et al., 2017). This evidence concerns the gene IL1B and cardiovascular disorder.