HMGB-1 exposure also seems to induce pro-inflammatory priming in microglial cells of aged brains (Fonken et al., 2016) and the microglial inhibitor named minocicline reduces reactive microgliosis and HMGB-1 release by activated glia (Hayakawa et al., 2008) Stroke. The gene discussed is HMGB1; the disease is stroke disorder.