HMGB-1 exposure also seems to induce pro-inflammatory priming in microglial cells of aged brains (Fonken et al., 2016) and the microglial inhibitor named minocicline reduces reactive microgliosis and HMGB-1 release by activated glia (Hayakawa et al., 2008) Stroke. This evidence concerns the gene HMGB1 and Stroke.