PIK3C2A and bipolar disorder: For example, variants in the kinase PIK3C2A, and the PI binding proteins UHRF1 (PI5P), SNAP91 and CAPN2 [PI(4,5)P2], RPTOR [PI(3,5)P2], AKT3 [PI(3,4)P2 and PI(3,4,5)P3] have been linked to schizophrenia patients (Goes et al., 2015) and another study identified PIK3C2A linked to schizophrenia and bipolar disorder (Ruderfer et al., 2014).