In a large study conducted in 74,026 individuals, a new locus was also identified with SNPs in INPP5D/SHIP1, the enzyme dephosphorylating PI(3,4,5)P3 into PI(3,4)P2, linking it to Alzheimer’s disease (Lambert et al., 2013). This evidence concerns the gene INPP5D and early-onset autosomal dominant Alzheimer disease.