PIK3CA and cerebral malformation: And finally, mosaic mutation at p.Glu17Lys in pleckstrin homology (PH) domain of AKT3, a predominant effector of PI3K signaling, causes an elevation in binding to phosphatidylinositol-3,4-bisphosphate, with patients exhibiting asymmetric cortical dysplasia, while constitutive mutation in other domains showed a range of brain malformations (Poduri et al., 2012; Alcantara et al., 2017).