An iPSC model for Lowe Syndrome has also been developed by Barnes et al., that suggests abnormalities in F-actin polymerization, WAVE-1 expression and altered PI(4,5)P2 levels in patient specific iPSC derived neurons, giving a further insight about the disease pathology at the cellular level (Barnes et al., 2018). Here, WASF1 is linked to oculocerebrorenal syndrome.