For example, variants in the kinase PIK3C2A, and the PI binding proteins UHRF1 (PI5P), SNAP91 and CAPN2 [PI(4,5)P2], RPTOR [PI(3,5)P2], AKT3 [PI(3,4)P2 and PI(3,4,5)P3] have been linked to schizophrenia patients (Goes et al., 2015) and another study identified PIK3C2A linked to schizophrenia and bipolar disorder (Ruderfer et al., 2014). Here, RPTOR is linked to schizophrenia.