The neurotrophin, brain-derived neurotrophic factor (BDNF) is an attractive therapeutic for many neurodegenerative diseases due to its broad neuroprotective effects promoting neuronal survival, synaptic plasticity and central nervous system (CNS) myelination (Chao, 2003; Longo and Massa, 2013; Fletcher et al., 2018a). The gene discussed is BDNF; the disease is neurodegenerative disease.