MAPT and amyloidosis: This is further demonstrated by the findings that induction of autophagy after the formation of mature tangles and plaques had no effect on cognitive deficits or other AD-like pathology, whereas increasing autophagy induction before the development of AD-like pathology reduced the levels of soluble tau, Aβ and amyloid plaques in 3xTg-AD mice (Majumder et al., 2011).