On the other hand, works done by others suggests that APP metabolites may also accumulate in cells through inhibition of autophagy before fusion with lysosome, such as genetic deletion of ATG7 or ATG5, which indicating that AD-like pathology may arise by perturbation at any step along the autophagy-lysosome pathway (Tian et al., 2011). This evidence concerns the gene ATG5 and Alzheimer disease.