SELE and relapsing-remitting multiple sclerosis: To test the efficacy of E-selectin administration in the most robust manner, we tested the approach prophylactically and therapeutically in active and passive models of chronic and relapsing-remitting MS, to overcome previous concerns that only in more of the milder relapsing disease settings would tolerance approaches have success (Liu and Wraith, 1995; Bai et al., 1997; Thurau et al., 1997).