Indeed, natalizumab, an antibody to α4 integrin the ligand for vascular CAM-1 (VCAM-1), was extremely effective in treating EAE (Zhang et al., 2003) and went on to show the ability to reduce relapses in MS patients by 68% compared to placebo, which far exceeded results for approved MS therapies at that time (Polman et al., 2006). This evidence concerns the gene VCAM1 and myeloid sarcoma.