SNCA and Parkinson disease: Given the pathological relevance of the misfolding and aggregation propensity of SNCA in synucleopathies as well as the proposed role of PTMs in SNCA’s misfolding, clearance and aggregation processes, the development of assays capable of detecting and quantifying monomeric and oligomeric SNCA, as well as its post-translationally modified forms (Vicente Miranda et al., 2017), is a key diagnostic and therapeutic focus of translational PD research (reviewed in Anderson et al., 2006; Kasuga et al., 2012; Oueslati, 2016; Parnetti et al., 2019).