Moreover, as pS129 SNCA is reported to be enriched in plasma of PD patients and to associate with aggregated/misfolded SNCA in Lewy bodies (Parnetti et al., 2019), our pS129 SNCA assay can be meaningfully applied to identify and validate pS129 SNCA modifiers employed as potential therapeutics for PD, serving as a non-invasive, potential wet biomarker in preclinical studies and clinical trials aimed at lowering pS129 SNCA levels with the objective of modulating SNCA oligomerization/aggregation. The gene discussed is SNCA; the disease is Parkinson disease.