Previous studies have shown the high radiosensitivity of EGFR‐mutant NSCLC.26, 27 Moreover, WBRT or focal RT can cause early and delayed blood brain barrier disruption, which presumably leads to an increase in TKI permeability.28 In addition, EGFR‐TKIs could enhance the radiation response at several levels, including cell cycle arrest, apoptosis induction, accelerated cellular repopulation, and DNA damage repair.29 Based on these biological rationales, radiation and EGFR‐TKI are expected to provide good combinational therapy. This evidence concerns the gene EGFR and non-small cell lung carcinoma.