Studies have been shown that mediators of angiogenesis may play an important role in the regulation of endothelial integrity and inflammation and it was possible that changes in the stability and functional properties of ZC3HC1 protein may play a role in the endothelial dysfunction (Schunkert et al., 2011), especially in the coronary heart disease and hypertension. Here, ZC3HC1 is linked to hypertensive disorder.