Among the iron metabolism genes (FTH1, TFR1 and DMT1), ferritin heavy chain 1 (FTH1) and transferrin receotor protein 1 (TFR1) were markedly up‐regulated in HCC cells treated with erastin and sorafenib, whereas knockdown of S1R inhibited these increases (Figure 5A). This evidence concerns the gene TMBIM4 and hepatocellular carcinoma.