In recent years, longitudinal studies have shown that the cognitive decline in DAT is a continuous process that takes place over a long period of time, and that the pathological changes of DAT are also part of a continuous process that begins decades before the appearance of cognitive symptoms (Fagan et al., 2014; Monsell et al., 2014; Resnick et al., 2010; Sutphen et al., 2015; Villemagne et al., 2011). Here, SLC6A3 is linked to Mental deterioration.