Furthermore, Barbazán et al. reported that luminal side of liver blood vessels contained fibronectin deposits that were enriched in mice bearing CRC and human livers affected with metastases, more importantly, CRC cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions, resulting in liver metastasis formation in vivo30. This evidence concerns the gene FN1 and colorectal carcinoma.