It showed a similar result with the immune deficient mice model (Fig. 4A,B), confirming that silencing PDK1 significantly inhibited liver metastasis in CRC, and the simultaneous administration of CPT further improved its efficacy by down-regulation of p-STAT3-Y705 (P < 0.01), which was independent of host immune status. The gene discussed is STAT3; the disease is colorectal carcinoma.