To strengthen the clinical translation, we further examined the efficacy of CPT with or without an unspecific PDK1 inhibitor (dichloroacetate, DCA), which also demonstrated that CPT or CPT plus DCA significantly reduced the liver metastasis of colon cancer, compared with the control group, moreover, the combined efficacy of CPT and DCA was better than that of single CPT treatment (Fig. S4). Here, PDK1 is linked to colonic neoplasm.