LEP and Hyperglycemia: Since AgRP neurons are required for leptin’s glucose-lowering properties3 and are known to be inhibited by leptin13,14, we further examined whether the activation of AgRP neurons by the excitatory DREADD virus AAV8-DIO-hM3Dq-mCherry could antagonize the leptin-induced normalization of hyperglycaemia in diabetic mice (ob/ob;AgRP-ires-cre).