Gene Ontology enrichment analysis, conducted using MSigDB)27,28, of the GRN subnetwork regulated by ETV4 and PPARG (Fig. 3) included terms highly relevant to disease processes in asthma, including response to corticosteroid (FDR = 2.94 × 10−5), regulation of immune system process (FDR = 8.92 × 10−4), and innate immune response (FDR = 5.89 × 10−3). This evidence concerns the gene GRN and asthma.