These top-ranked regulators included STAT6, a TF known to have a central role in allergy through its modulation of Th2 cell differentiation, cell surface marker expression, and class-switching of immunoglobulins45, as well as, NFIL3, which is induced by STAT6 and regulates IgE production, an immunoglobulin central to allergy46. Here, IGHE is linked to allergic disease.