Here using new tools available to study centriole amplification in MCC –a home-made Deup1 antibody and the Plk4 inhibitor centrinone- we further investigate the relationship between the centrosome organelle and the dynamics of centriole amplification by (i) characterizing the centrosome behavior during centriole amplification and (ii) assessing the dynamics of amplification in cells depleted from one or both centrosomal centrioles. This evidence concerns the gene DEUP1 and Merkel cell skin cancer.