Importantly, we have demonstrated that the histologic features of BCCs in Ptch1+/−/ODCt/C57BL/6 mice are similar to those in GS patients, including palisading at the edge of tumor nests, retraction from surrounding stroma, the lack of keratin pearl, and the characteristic expression pattern of marker biomolecules11. The gene discussed is PTCH1; the disease is neoplasm.