Diet accounted for the largest proportion of the phenotypic variation in metabolic (for example, 48% of the phenotypic variability for final body weight is explained by diet), immunoglobulin (up to 37% for IgA/IgM ratio), and pathophysiological traits (up to 46% NAFLD ballooning; Supplementary Table 1, Supplementary Data 1). This evidence concerns the gene CD79A and metabolic dysfunction-associated steatotic liver disease.