LEP and colorectal carcinoma: With a significant overall correlation (P < 0.001, Fig. 2e), a positive correlation was found between MPS-1 expression and leptin level in obese CRC patients (R2 = 0.255, P = 0.023, Fig. 2f) and in all CRC patients from cohort 2 (R2 = 0.220, P = 0.002, Fig. 2g) but not in non-obese cases (R2 = 0.025, P > 0.05, Fig. 2h).