Stabilized PML further controls oncogenesis using bi-fold method: (a) by down-regulating pro-oncogenic Survivin and (b) by acting as a scaffold molecule, causing possible inactivation of active pAKT and thus stabilization of Foxo3a that further activates important cell cycle regulators and markers of tumor suppression: p21 and p27. This evidence concerns the gene BIRC5 and neoplasm.