To evaluate the potential use of the CSC score as an independent prognostic biomarker, a multivariate analysis was performed including all the significant variables from the univariate analyses (age, tumor node metastasis (TNM) staging, tumor size, lymph node involvement, CDKN1A, ITGA6, SNAI1, and the CSC score). This evidence concerns the gene CDKN1A and neoplasm.