In this dataset, we identified 200 patients with BRCA mutations, BRCA methylation, defects of PTEN, defects of FA (Fanconi anemia) genes, Ras-related associated with diabetes (RAD) genes, and ATM (ataxia telangiectasia) genes (i.e., ATM, ataxia telangiectasia and Rad3-related (ATR), and CHEK1/2), as well as the amplification of EMSY as HR-defective tumors21. This evidence concerns the gene ATR and ataxia telangiectasia.