For the 423 genes in MEturquoise, we determined 18 genes as hubgenes (SMARCD1, CBX1, HCFC1, RBM12B, RCC2, NUP205, ECT2, PRIM2, RBM28, COPS7B, PRRC2A, GPR107, ANKRD52, TUBA1B, ATXN7L3, FUS, MCM8 and RACGAP1), which were highly associated with MEturquoise with Module Membership (MM) scores > 0.8 (Fig. 10a) and were remarkably correlated with the survival time, pathology grade and TNM stage in patients with HCC (Fig. 10b). The gene discussed is MCM8; the disease is hepatocellular carcinoma.