The M2 phenotype of regulated glycolytic enzyme pyruvate kinase (PKM2) and lactate dehydrogenase A (LDHA), another downstream component of an aerobic glycolytic pathway were found to be over-expressed and have shown a profound effect on acute myeloid leukemia (AML) and CML [5]. This evidence concerns the gene LDHA and chronic myelogenous leukemia, BCR-ABL1 positive.