To investigate the functions affected by CCR5-deficiency in astrocytes in more detail, DEGs in which upregulation during infection was impaired by CCR5-deficiency were ranked according to the fold-changes, calculated by DESeq2, occurring between T. gondii-infected cells from WT and CCR5KO mice, and the expression profiles of the top 20 genes were compared (Fig. 1a). This evidence concerns the gene CCR5 and infection.