Another hypothesis is that HLA-G expressed on the skin of vitiligo patients interacts with KIR2DL4 receptors from NK cells, and this interaction may induce the production of proinflammatory cytokines such as IFN-γ, TNF-α, IL-1α, IL-1β, IL-6, and IL-8 [48]. This evidence concerns the gene CXCL8 and vitiligo.