After using the adjuvant to improve the poor bioavailability of curcumin, natural borneol and curcumin synergistically induce the apoptosis of human melanoma A375 cells with the involvement of the downregulation of Akt and ERK1/2 phosphorylation and the upregulation of phosphorylated JNK [26]. This evidence concerns the gene MAPK8 and melanoma.