APP and Alzheimer disease: As the current transgenic mouse studies found CatB enhancement linked to reduced Aβ pathology and improved synaptic and cognitive measures, it is also relevant to point out a study showing that aspirin induces lysosomal biogenesis in vitro with a corresponding increase in CatB activity, as well as in 5× familial AD mice with corresponding reductions in APP-βCTF and Aβ peptides [66].