CLEC1B and Disseminated intravascular coagulation: DENV also reduces platelet count through direct destruction of platelets by (1) directed binding of anti-dengue NS1 antibodies to platelets leading to complement-mediated lysis [76,77], (2) high levels E-selection on endothelial cells promoting platelet adhesion and clearance [78], (3) direct binding of DENV to platelets via lectin receptors such as CLEC-2 and DC-SIGN [74] and disseminated intravascular coagulation (DIC) [79] and increased apoptosis due to binding of DC-SIGN and caspases [80].