Moreover, evidence in tumor biology suggests that the IGF signaling pathway is important for tumorigenesis and tumor cell survival and provides chemoresistance ability in several types of cancers, including cancers of the liver, lung, endometrium, prostate, colon, rectum, pancreas, and ovary [222,223,235,236,237,238,239,240,241,242,243]. Here, IGF1 is linked to cancer.