RARRES2 and gestational diabetes: However, a recent meta-analysis by Zhou et al., evaluating 11 studies carried out between 2010 and 2017 and including a total of 742 GDM patients and 840 normal pregnant women [229], reported that the overall levels of plasma chemerin in GDM women were significantly increased when compared with healthy pregnant ones and that this difference was more evident in the second- than in the third-trimester.