It is noteworthy that elevated chemerin levels in the DHT-induced rat PCOS model were positively related to increased granulosa cell apoptosis [19] and that women presenting higher chemerin concentrations in follicular fluid had significantly fewer oocytes and lower high-quality embryo rates [184], suggesting that chemerin could actually be involved in folliculogenesis disruption at the origin of PCOS [19] (Figure 12). Here, RARRES2 is linked to polycystic ovary syndrome.