On the contrary, resistin mRNA levels in adipocytes have been found to be twice as high in PCOS patients compared to controls [214] (Figure 11) and significantly decreased after laparoscopic ovarian electrocautery [215], suggesting that, although systemic resistin does not seem to be actively involved in PCOS pathogenesis, it may act as a local determining factor for this syndrome [47,214] (Figure 12). The gene discussed is RETN; the disease is polycystic ovary syndrome.