A Severe Combined ImmunoDeficiency, SCID-humanized mouse model infected with different strains of the Measles virus showed a productive infection occurring in thymic epithelial and myelo-monocytic cells, leading to a rapid depletion of CD4+CD8+ double positive (DP) thymocytes by apoptosis, and contributing to a long-term alteration of immune responses [116]. This evidence concerns the gene CD4 and infection.