Since upregulation of p90RSK has been reported in various human diseases, aberrant activation of p90RSK plays an important role in the pathogenesis of some tumors and metabolic diseases (e.g., diabetic heart disease, atherosclerosis, diabetic nephropathy, and liver fibrosis) [31,32,33,34,35]. Here, RPS6KA1 is linked to Hepatic fibrosis.